TransPath

TransPath is a database on signal transduction pathways that are modeled as bipartite graphs with molecules and reactions as node classes. It offers molecular details of the signal flow from the cell surface into the nucleus. Information in TRANSPATH is hierarchically structured. There are several orthogonal hierarchies of molecules, according to species information, according to the status of modifications and participation in the multicomponent complexes, and according to their function in the signal flow. Reactions are presented at three hierarchical levels, molecular evidence, pathway steps, semantic. All information has been manually curated by experts from the full-text publications. TRANSPATH and accompanying tools can be used for data visualization and modeling and for the analysis of gene expression data.

Citation: Krull M, Pistor S, Voss N, Kel A, Reuter I, Kronenberg D, Michael H, Schwarzer K, Potapov A, Choi C, Kel-Margoulis O, Wingender E. (2006)TRANSPATH: an information resource for storing and visualizing signaling pathways and their pathological aberrations. Nucleic Acids Res. 34(Database issue):D546-51. PMID: 16381929